E-ISSN 0331-8753 | ISSN 0794-5698
 

Original Research 


Prophylactic Effect of Cyperus Esculentus Milk on High Dose Acetaminophen Model of Hepatic Toxicity in Wistar Rats

Dorcas Akinloye, Oluseyi Akinloye, Adeola Adejumo.

Abstract
Cyperuses esculentus is a wholesome nut with notable nutritional and medicinal benefits. This study investigated the prophylactic impact of Cyperus esculentus milk extract (CE) on high dose acetaminophen-induced liver impairment in experimental rats. Thirty rats of weight between 155-220 grams were randomly distributed into 5 groups (n=5). Groups 1 and 2 were without treatment, while rats in groups 3, 4, 5 and 6 were orally administered 8.57mg ascorbic acid, 100 mg/kg, 200mg/kg and 400mg/kg of body weight CE respectively for 21 days. On the 22nd day of the experiment, 1g/kg body weight of acetaminophen was administered orally to rats in group 2 to 5. The serum and liver was collected for analyses. Histopathology of the liver was delved into. CE and the standard drug (ascorbic acid) at selected doses appreciably decreased serum activities (p<0.05) of AST, ALT, ALP, and concentration of malondialdehyde which were increased by acetaminophen. Decreased serum GST activity caused by acetaminophen was significantly prevented by the extract and ascorbic acid. In the liver, acetaminophen potently decreased activities AST, ALT, ALP, and concentration of malondialdehyde, however increased the activity of GST when compared to control at p < 0.05. CE and ascorbic acid markedly (p<0.05) prevented these effects with CE producing dose dependent moderation in AST and ALT activities and MDA concentration. However, increased activity of GST was not changed by ascorbic acid. The present study revealed that C. esculentus milk extracts prevented hepatic damage caused by high dose acetaminophen in rats.

Key words: Acetaminophen, Cyperus esculentus, biomarkers, hepatoprotective.


 
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How to Cite this Article
Pubmed Style

Akinloye D, Akinloye O, Adejumo A, . Prophylactic Effect of Cyperus Esculentus Milk on High Dose Acetaminophen Model of Hepatic Toxicity in Wistar Rats. Nig. J. Basic Appl. Sci.. 2019; 27(1): 105-113. doi:10.4314/njbas.v27i1.14


Web Style

Akinloye D, Akinloye O, Adejumo A, . Prophylactic Effect of Cyperus Esculentus Milk on High Dose Acetaminophen Model of Hepatic Toxicity in Wistar Rats. http://www.njbas-udus.com/?mno=1095 [Access: March 28, 2020]. doi:10.4314/njbas.v27i1.14


AMA (American Medical Association) Style

Akinloye D, Akinloye O, Adejumo A, . Prophylactic Effect of Cyperus Esculentus Milk on High Dose Acetaminophen Model of Hepatic Toxicity in Wistar Rats. Nig. J. Basic Appl. Sci.. 2019; 27(1): 105-113. doi:10.4314/njbas.v27i1.14



Vancouver/ICMJE Style

Akinloye D, Akinloye O, Adejumo A, . Prophylactic Effect of Cyperus Esculentus Milk on High Dose Acetaminophen Model of Hepatic Toxicity in Wistar Rats. Nig. J. Basic Appl. Sci.. (2019), [cited March 28, 2020]; 27(1): 105-113. doi:10.4314/njbas.v27i1.14



Harvard Style

Akinloye, D. ., Akinloye, O. ., Adejumo, A. . & (2019) Prophylactic Effect of Cyperus Esculentus Milk on High Dose Acetaminophen Model of Hepatic Toxicity in Wistar Rats. Nig. J. Basic Appl. Sci., 27 (1), 105-113. doi:10.4314/njbas.v27i1.14



Turabian Style

Akinloye, Dorcas , Oluseyi Akinloye, Adeola Adejumo, and . 2019. Prophylactic Effect of Cyperus Esculentus Milk on High Dose Acetaminophen Model of Hepatic Toxicity in Wistar Rats. Nigerian Journal of Basic and Applied Sciences, 27 (1), 105-113. doi:10.4314/njbas.v27i1.14



Chicago Style

Akinloye, Dorcas , Oluseyi Akinloye, Adeola Adejumo, and . "Prophylactic Effect of Cyperus Esculentus Milk on High Dose Acetaminophen Model of Hepatic Toxicity in Wistar Rats." Nigerian Journal of Basic and Applied Sciences 27 (2019), 105-113. doi:10.4314/njbas.v27i1.14



MLA (The Modern Language Association) Style

Akinloye, Dorcas , Oluseyi Akinloye, Adeola Adejumo, and . "Prophylactic Effect of Cyperus Esculentus Milk on High Dose Acetaminophen Model of Hepatic Toxicity in Wistar Rats." Nigerian Journal of Basic and Applied Sciences 27.1 (2019), 105-113. Print. doi:10.4314/njbas.v27i1.14



APA (American Psychological Association) Style

Akinloye, D. ., Akinloye, O. ., Adejumo, A. . & (2019) Prophylactic Effect of Cyperus Esculentus Milk on High Dose Acetaminophen Model of Hepatic Toxicity in Wistar Rats. Nigerian Journal of Basic and Applied Sciences, 27 (1), 105-113. doi:10.4314/njbas.v27i1.14





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