E-ISSN 0331-8753 | ISSN 0794-5698
 

Review Article 


Sickle Cell Disease among Blacks; the Possible Pivotal Role of Precision Medicine: A Focused Review on Management of Pain

M. A. Ndakotsu and S. A. Balarabe.

Abstract
Sickle Cell Disease (SCD) occurs commonly in sub- Saharan African region. For instance, out of the estimated 305,800 babies born annually with SCD worldwide about 75% occurred in sub-Saharan Africa (SSA). Vasoocclusive painful crisis, is the prototype clinical event among SCD patients with nearly all SCD persons experiencing the episode during their lifetime. Additionally, acute vasooculusive pain crises may eventually progressed to chronic pain, resulting in poor quality of life associated with other morbidities, including anxiety, depression and dependence on pain medications. Transformation and technological development that brought about, new clinical approaches and treatments have increased rates of survival in patients with Sickle Cell Disease (SCD). However, the overall life expectancy of such patients remains shorter than other normal populations. Therefore, should be guided by an individualized précised prescribing and monitoring protocol. To this end, the concept of precision medicine that is predicated on using practical application of human genomics provide an evolving set of translational research goals in the management of pain in sickle cell disease. This review tend to shed light on this new concept, hoping that the review will facilitate improved and more accessible care for all patients leaving with sickle cell disease.

Key words: Sickle cell disease, precision medicine, pain management, Sickle cell crisis,Hydroxyurea.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by M. A. Ndakotsu and S. A. Balarabe
on Google
on Google Scholar
Article Statistics
 Viewed: 1605
Downloaded: 2


How to Cite this Article
Pubmed Style

M. A. Ndakotsu and S. A. Balarabe. Sickle Cell Disease among Blacks; the Possible Pivotal Role of Precision Medicine: A Focused Review on Management of Pain. Nig. J. Basic Appl. Sci.. 2019; 27(2): 142-150. doi:10.4314/njbas.v27i2.19


Web Style

M. A. Ndakotsu and S. A. Balarabe. Sickle Cell Disease among Blacks; the Possible Pivotal Role of Precision Medicine: A Focused Review on Management of Pain. http://www.njbas-udus.com/?mno=20892 [Access: March 29, 2020]. doi:10.4314/njbas.v27i2.19


AMA (American Medical Association) Style

M. A. Ndakotsu and S. A. Balarabe. Sickle Cell Disease among Blacks; the Possible Pivotal Role of Precision Medicine: A Focused Review on Management of Pain. Nig. J. Basic Appl. Sci.. 2019; 27(2): 142-150. doi:10.4314/njbas.v27i2.19



Vancouver/ICMJE Style

M. A. Ndakotsu and S. A. Balarabe. Sickle Cell Disease among Blacks; the Possible Pivotal Role of Precision Medicine: A Focused Review on Management of Pain. Nig. J. Basic Appl. Sci.. (2019), [cited March 29, 2020]; 27(2): 142-150. doi:10.4314/njbas.v27i2.19



Harvard Style

M. A. Ndakotsu and S. A. Balarabe (2019) Sickle Cell Disease among Blacks; the Possible Pivotal Role of Precision Medicine: A Focused Review on Management of Pain. Nig. J. Basic Appl. Sci., 27 (2), 142-150. doi:10.4314/njbas.v27i2.19



Turabian Style

M. A. Ndakotsu and S. A. Balarabe. 2019. Sickle Cell Disease among Blacks; the Possible Pivotal Role of Precision Medicine: A Focused Review on Management of Pain. Nigerian Journal of Basic and Applied Sciences, 27 (2), 142-150. doi:10.4314/njbas.v27i2.19



Chicago Style

M. A. Ndakotsu and S. A. Balarabe. "Sickle Cell Disease among Blacks; the Possible Pivotal Role of Precision Medicine: A Focused Review on Management of Pain." Nigerian Journal of Basic and Applied Sciences 27 (2019), 142-150. doi:10.4314/njbas.v27i2.19



MLA (The Modern Language Association) Style

M. A. Ndakotsu and S. A. Balarabe. "Sickle Cell Disease among Blacks; the Possible Pivotal Role of Precision Medicine: A Focused Review on Management of Pain." Nigerian Journal of Basic and Applied Sciences 27.2 (2019), 142-150. Print. doi:10.4314/njbas.v27i2.19



APA (American Psychological Association) Style

M. A. Ndakotsu and S. A. Balarabe (2019) Sickle Cell Disease among Blacks; the Possible Pivotal Role of Precision Medicine: A Focused Review on Management of Pain. Nigerian Journal of Basic and Applied Sciences, 27 (2), 142-150. doi:10.4314/njbas.v27i2.19





Most Viewed Articles
  • Isolation and Identification of Fungi Associated with the Spoilage of Sweet Orange (Citrus Sinensis) Fruits In Sokoto State
    I.Y. Tafinta, K.Shehu, H. Abdulganiyyu, A.M. Rabe and A. Usman
    Nig. J. Basic Appl. Sci.. 2013; 21(3): 193-196
    » Abstract & References

  • Heavy Metals and Physicochemical Properties of Soils in Kano Urban Agricultural Lands
    U.M. Dawaki, A.U. Dikko, S.S. Noma and U. Aliyu
    Nig. J. Basic Appl. Sci.. 2013; 21(3): 239-246
    » Abstract & References

  • Study on Biochemical Indices of Liver Function Tests of Albino Rats Supplemented with Three Sources of Vegetable Oils [English]
    K.E. Imafidon and L.O. Okunrobo
    Nig. J. Basic Appl. Sci.. 2012; 20(2): 105-110
    » Abstract

  • Effect of Sources of Organic Manure on Growth and Yields of Okra (Abelmoschus esculentus L.) in Sokoto, Nigeria [English]
    R.A. Tiamiyu, H.G. Ahmed and A.S. Muhammad
    Nig. J. Basic Appl. Sci.. 2012; 20(3): 213-216
    » Abstract

  • Optimum Temperature and Thermal Stability of Crude Polyphenol Oxidase from some Common Fruits
    AB Bello, MS Sule
    Nig. J. Basic Appl. Sci.. 2012; 20(1): 27-31
    » Abstract

  • Most Downloaded
  • Isolation and Identification of Fungi Associated with the Spoilage of Sweet Orange (Citrus Sinensis) Fruits In Sokoto State
    I.Y. Tafinta, K.Shehu, H. Abdulganiyyu, A.M. Rabe and A. Usman
    Nig. J. Basic Appl. Sci.. 2013; 21(3): 193-196
    » Abstract & References

  • Optimization of Steam Distillation of Essential Oil of Eucalyptus tereticornis by Response Surface Methodology [English]
    M.S. Galadima, A.S. Ahmed, A.S. Olawale and I. M. Bugaje
    Nig. J. Basic Appl. Sci.. 2012; 20(4): 368-372
    » Abstract

  • Biogas production through Co-digestion of palm oil mill effluent with cow manure
    Umar Hayatu Sidik, Firdausi Bin Razali, Sharifah Rafidah Wan Alwi, Fadimtu Maigari
    Nig. J. Basic Appl. Sci.. 2013; 21(1): 79-84
    » Abstract

  • The Swelling Behaviour of Polystyrene (PS)/ Polyvinylacetate (Pvac) Blends in Different Solvents and the Effects of -Cellulose used as Filler on the Electrical Conductivity. [English]
    P. A. P. Mamza and B.T. Nwufo
    Nig. J. Basic Appl. Sci.. 2008; 16(2): 165 -
    » Abstract

  • Heavy Metals and Physicochemical Properties of Soils in Kano Urban Agricultural Lands
    U.M. Dawaki, A.U. Dikko, S.S. Noma and U. Aliyu
    Nig. J. Basic Appl. Sci.. 2013; 21(3): 239-246
    » Abstract & References

  • Most Cited Articles