E-ISSN 2756-4843 | ISSN 0794-5698
 
2020, Vol: 28, Issue: 2
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Review Article 


Sickle Cell Disease among Blacks; the Possible Pivotal Role of Precision Medicine: A Focused Review on Management of Pain

M. A. Ndakotsu and S. A. Balarabe.

Abstract
Sickle Cell Disease (SCD) occurs commonly in sub- Saharan African region. For instance, out of the estimated 305,800 babies born annually with SCD worldwide about 75% occurred in sub-Saharan Africa (SSA). Vasoocclusive painful crisis, is the prototype clinical event among SCD patients with nearly all SCD persons experiencing the episode during their lifetime. Additionally, acute vasooculusive pain crises may eventually progressed to chronic pain, resulting in poor quality of life associated with other morbidities, including anxiety, depression and dependence on pain medications. Transformation and technological development that brought about, new clinical approaches and treatments have increased rates of survival in patients with Sickle Cell Disease (SCD). However, the overall life expectancy of such patients remains shorter than other normal populations. Therefore, should be guided by an individualized précised prescribing and monitoring protocol. To this end, the concept of precision medicine that is predicated on using practical application of human genomics provide an evolving set of translational research goals in the management of pain in sickle cell disease. This review tend to shed light on this new concept, hoping that the review will facilitate improved and more accessible care for all patients leaving with sickle cell disease.

Key words: Sickle cell disease, precision medicine, pain management, Sickle cell crisis,Hydroxyurea.


 
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Pubmed Style

M. A. Ndakotsu and S. A. Balarabe. Sickle Cell Disease among Blacks; the Possible Pivotal Role of Precision Medicine: A Focused Review on Management of Pain. Nig. J. Basic Appl. Sci.. 2019; 27(2): 142-150. doi:10.4314/njbas.v27i2.19

Web Style

M. A. Ndakotsu and S. A. Balarabe. Sickle Cell Disease among Blacks; the Possible Pivotal Role of Precision Medicine: A Focused Review on Management of Pain. http://www.njbas-udus.com/?mno=20892 [Access: March 25, 2021]. doi:10.4314/njbas.v27i2.19

AMA (American Medical Association) Style

M. A. Ndakotsu and S. A. Balarabe. Sickle Cell Disease among Blacks; the Possible Pivotal Role of Precision Medicine: A Focused Review on Management of Pain. Nig. J. Basic Appl. Sci.. 2019; 27(2): 142-150. doi:10.4314/njbas.v27i2.19


Vancouver/ICMJE Style

M. A. Ndakotsu and S. A. Balarabe. Sickle Cell Disease among Blacks; the Possible Pivotal Role of Precision Medicine: A Focused Review on Management of Pain. Nig. J. Basic Appl. Sci.. (2019), [cited March 25, 2021]; 27(2): 142-150. doi:10.4314/njbas.v27i2.19


Harvard Style

M. A. Ndakotsu and S. A. Balarabe (2019) Sickle Cell Disease among Blacks; the Possible Pivotal Role of Precision Medicine: A Focused Review on Management of Pain. Nig. J. Basic Appl. Sci., 27 (2), 142-150. doi:10.4314/njbas.v27i2.19


Turabian Style

M. A. Ndakotsu and S. A. Balarabe. 2019. Sickle Cell Disease among Blacks; the Possible Pivotal Role of Precision Medicine: A Focused Review on Management of Pain. Nigerian Journal of Basic and Applied Sciences, 27 (2), 142-150. doi:10.4314/njbas.v27i2.19


Chicago Style

M. A. Ndakotsu and S. A. Balarabe. "Sickle Cell Disease among Blacks; the Possible Pivotal Role of Precision Medicine: A Focused Review on Management of Pain." Nigerian Journal of Basic and Applied Sciences 27 (2019), 142-150. doi:10.4314/njbas.v27i2.19


MLA (The Modern Language Association) Style

M. A. Ndakotsu and S. A. Balarabe. "Sickle Cell Disease among Blacks; the Possible Pivotal Role of Precision Medicine: A Focused Review on Management of Pain." Nigerian Journal of Basic and Applied Sciences 27.2 (2019), 142-150. Print. doi:10.4314/njbas.v27i2.19


APA (American Psychological Association) Style

M. A. Ndakotsu and S. A. Balarabe (2019) Sickle Cell Disease among Blacks; the Possible Pivotal Role of Precision Medicine: A Focused Review on Management of Pain. Nigerian Journal of Basic and Applied Sciences, 27 (2), 142-150. doi:10.4314/njbas.v27i2.19




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