E-ISSN 2756-4843 | ISSN 0794-5698
 

Original Research 


Prevalence of Extended-Spectrum Beta-Lactamases (ESBLs) and Metallo-BetaLactamases (MBLs) Among Healthy and Hospitalized Children in Abraka and Eku Communities, Delta State, Nigeria

OLIVIA SOCHI EGBULE, Erkison Ewomazino Odih.

Abstract
Abstract
This study was conducted to detect the prevalence of metallo-beta-lactamases (MBLs) and extended-spectrum beta-lactamases (ESBLs) in bacterial isolates from clinical and community settings in Delta State, Nigeria. Eighty four isolates obtained from blood, urine wound and stool of patients and community subjects were analyzed and identified by standard microbiological methods. Carbapenemase detection was carried out using modified Hodge test. EDTA-disc synergy test was used to detect MBL production. ESBLs production was determined by double disc synergy test (DDST). ESBL production was detected in 36.7% isolates of Escherichia coli, 37.5% of Pseudomonas aeruginosaand 75% of Klebsiellapneumoniae. Co-production of MBL and ESBL was observed in 31.82% of the isolates. The study observed 2 major troubling findings. The first is the prevalence and co-production of MBLs and ESBLs both in hospitalized patients and in isolates of healthy community children. Second, antibiotic resistance is no longer only associated with selective pressure but may stably persist in bacteria. There is therefore the need for antibiotic alternative research.

Key words: Keywords: Antibiotic resistance, Multidrug resistance, Healthy children, Beta-lactamases, Plasmids


 
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Pubmed Style

EGBULE OS, Odih EE. Prevalence of Extended-Spectrum Beta-Lactamases (ESBLs) and Metallo-BetaLactamases (MBLs) Among Healthy and Hospitalized Children in Abraka and Eku Communities, Delta State, Nigeria. Nig. J. Basic Appl. Sci.. 2020; 28(1): 7-14. doi:10.4314/njbas.v28i1.2


Web Style

EGBULE OS, Odih EE. Prevalence of Extended-Spectrum Beta-Lactamases (ESBLs) and Metallo-BetaLactamases (MBLs) Among Healthy and Hospitalized Children in Abraka and Eku Communities, Delta State, Nigeria. http://www.njbas-udus.com/?mno=232166 [Access: November 08, 2020]. doi:10.4314/njbas.v28i1.2


AMA (American Medical Association) Style

EGBULE OS, Odih EE. Prevalence of Extended-Spectrum Beta-Lactamases (ESBLs) and Metallo-BetaLactamases (MBLs) Among Healthy and Hospitalized Children in Abraka and Eku Communities, Delta State, Nigeria. Nig. J. Basic Appl. Sci.. 2020; 28(1): 7-14. doi:10.4314/njbas.v28i1.2



Vancouver/ICMJE Style

EGBULE OS, Odih EE. Prevalence of Extended-Spectrum Beta-Lactamases (ESBLs) and Metallo-BetaLactamases (MBLs) Among Healthy and Hospitalized Children in Abraka and Eku Communities, Delta State, Nigeria. Nig. J. Basic Appl. Sci.. (2020), [cited November 08, 2020]; 28(1): 7-14. doi:10.4314/njbas.v28i1.2



Harvard Style

EGBULE, O. S. & Odih, . E. E. (2020) Prevalence of Extended-Spectrum Beta-Lactamases (ESBLs) and Metallo-BetaLactamases (MBLs) Among Healthy and Hospitalized Children in Abraka and Eku Communities, Delta State, Nigeria. Nig. J. Basic Appl. Sci., 28 (1), 7-14. doi:10.4314/njbas.v28i1.2



Turabian Style

EGBULE, OLIVIA SOCHI, and Erkison Ewomazino Odih. 2020. Prevalence of Extended-Spectrum Beta-Lactamases (ESBLs) and Metallo-BetaLactamases (MBLs) Among Healthy and Hospitalized Children in Abraka and Eku Communities, Delta State, Nigeria. Nigerian Journal of Basic and Applied Sciences, 28 (1), 7-14. doi:10.4314/njbas.v28i1.2



Chicago Style

EGBULE, OLIVIA SOCHI, and Erkison Ewomazino Odih. "Prevalence of Extended-Spectrum Beta-Lactamases (ESBLs) and Metallo-BetaLactamases (MBLs) Among Healthy and Hospitalized Children in Abraka and Eku Communities, Delta State, Nigeria." Nigerian Journal of Basic and Applied Sciences 28 (2020), 7-14. doi:10.4314/njbas.v28i1.2



MLA (The Modern Language Association) Style

EGBULE, OLIVIA SOCHI, and Erkison Ewomazino Odih. "Prevalence of Extended-Spectrum Beta-Lactamases (ESBLs) and Metallo-BetaLactamases (MBLs) Among Healthy and Hospitalized Children in Abraka and Eku Communities, Delta State, Nigeria." Nigerian Journal of Basic and Applied Sciences 28.1 (2020), 7-14. Print. doi:10.4314/njbas.v28i1.2



APA (American Psychological Association) Style

EGBULE, O. S. & Odih, . E. E. (2020) Prevalence of Extended-Spectrum Beta-Lactamases (ESBLs) and Metallo-BetaLactamases (MBLs) Among Healthy and Hospitalized Children in Abraka and Eku Communities, Delta State, Nigeria. Nigerian Journal of Basic and Applied Sciences, 28 (1), 7-14. doi:10.4314/njbas.v28i1.2





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