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Original Research 


Hypoglycemic and Hypolipidemic Effect of Methanol Extract of Hibiscus Sabdariffa Seed in Alloxan Induced Diabetic Albino Rats

F. S. Adefolalu, J. S. Salawa, T. Y. Gara and A. N. Abubakar.

Abstract
This study investigated the hypoglycemic and hypolipidemic effect of the oral administration of methanol extract of Hibiscus sabdariffa seed in alloxan induced diabetic albino rats. Two different doses (200 and 400 mg/kg) of the methanol extract of Hibiscus sabdariffa seed was administered daily to two groups of diabetic rats for a period of two weeks. Metformin (250 mg/kg) was given as the reference standard drug. Phytochemical, acute toxicity, fasting blood glucose, body weight, cholesterol, triglyceride and lipoproteins levels were determined using standard methods. Acute toxicity of methanol extract of Hibiscus sabdariffa seed was estimated to be greater than 5000 mg/kg body weight. There was an initial decrease in the body weight of the experimental animals after induction of diabetes but increased significantly (p<0.05) by the second week of treatment. The fasting blood glucose levels of the treated diabetic rats were significantly decreased at the second week of treatment with the group that received 400 mg/kg of extract recording the lowest fasting blood glucose level. The cholesterol, triglyceride and low density lipoproteins levels of the diabetic treated rats were significantly reduced while the high density lipoproteins levels were significantly increased. It can therefore be concluded that Hibiscus sabdariffa seed has the ability to lower blood sugar and maintain a stable lipid level.

Key words: Hypoglycemic, hypolipidemic, Alloxan, phytochemical, Hibiscus sabdariffa


 
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How to Cite this Article
Pubmed Style

Adefolalu FS, Salawa JS, . Hypoglycemic and Hypolipidemic Effect of Methanol Extract of Hibiscus Sabdariffa Seed in Alloxan Induced Diabetic Albino Rats. Nig. J. Basic Appl. Sci.. 2019; 27(2): 151-156. doi:10.4314/njbas.v27i2.20

Web Style

Adefolalu FS, Salawa JS, . Hypoglycemic and Hypolipidemic Effect of Methanol Extract of Hibiscus Sabdariffa Seed in Alloxan Induced Diabetic Albino Rats. http://www.njbas-udus.com/?mno=26494 [Access: March 29, 2020]. doi:10.4314/njbas.v27i2.20

AMA (American Medical Association) Style

Adefolalu FS, Salawa JS, . Hypoglycemic and Hypolipidemic Effect of Methanol Extract of Hibiscus Sabdariffa Seed in Alloxan Induced Diabetic Albino Rats. Nig. J. Basic Appl. Sci.. 2019; 27(2): 151-156. doi:10.4314/njbas.v27i2.20


Vancouver/ICMJE Style

Adefolalu FS, Salawa JS, . Hypoglycemic and Hypolipidemic Effect of Methanol Extract of Hibiscus Sabdariffa Seed in Alloxan Induced Diabetic Albino Rats. Nig. J. Basic Appl. Sci.. (2019), [cited March 29, 2020]; 27(2): 151-156. doi:10.4314/njbas.v27i2.20


Harvard Style

Adefolalu, F. S., Salawa, . J. S. & (2019) Hypoglycemic and Hypolipidemic Effect of Methanol Extract of Hibiscus Sabdariffa Seed in Alloxan Induced Diabetic Albino Rats. Nig. J. Basic Appl. Sci., 27 (2), 151-156. doi:10.4314/njbas.v27i2.20


Turabian Style

Adefolalu, F. S., J. S. Salawa, and T. Y. Gara and A. N. Abubakar. 2019. Hypoglycemic and Hypolipidemic Effect of Methanol Extract of Hibiscus Sabdariffa Seed in Alloxan Induced Diabetic Albino Rats. Nigerian Journal of Basic and Applied Sciences, 27 (2), 151-156. doi:10.4314/njbas.v27i2.20


Chicago Style

Adefolalu, F. S., J. S. Salawa, and T. Y. Gara and A. N. Abubakar. "Hypoglycemic and Hypolipidemic Effect of Methanol Extract of Hibiscus Sabdariffa Seed in Alloxan Induced Diabetic Albino Rats." Nigerian Journal of Basic and Applied Sciences 27 (2019), 151-156. doi:10.4314/njbas.v27i2.20


MLA (The Modern Language Association) Style

Adefolalu, F. S., J. S. Salawa, and T. Y. Gara and A. N. Abubakar. "Hypoglycemic and Hypolipidemic Effect of Methanol Extract of Hibiscus Sabdariffa Seed in Alloxan Induced Diabetic Albino Rats." Nigerian Journal of Basic and Applied Sciences 27.2 (2019), 151-156. Print. doi:10.4314/njbas.v27i2.20


APA (American Psychological Association) Style

Adefolalu, F. S., Salawa, . J. S. & (2019) Hypoglycemic and Hypolipidemic Effect of Methanol Extract of Hibiscus Sabdariffa Seed in Alloxan Induced Diabetic Albino Rats. Nigerian Journal of Basic and Applied Sciences, 27 (2), 151-156. doi:10.4314/njbas.v27i2.20




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