ISSN 0331-8753
 

Original Research 


Oral Hypoglycaemic Agent Metformin Reduces Oxidative Stress and Improves Kidney Histology in Streptozotocin-induced Diabetic Rats

Umar Zayyanu Usman, Mahaneem Mohamed, Ainul Bhiyah Binti Abu Bakar, Aminu Ishaka.

Abstract
ABSTRACT
ABSTRACT
Background: Persistent hyperglycaemia results in complications in diabetes mellitus (DM) and metformin is the baseline drug used in diabetic management. The effect of metformin on fasting blood glucose (FBG), homogenized kidney tissue malonyldehyde (MDA), protein carbonyls (PCO), total antioxidant capacity (TAC) and histology in streptozotocin-induced diabetic rats was investigated.
Methods: Eighteen Sprague Dawley rats were assigned into three groups (n= 6 rats per group i.e. A; negative control on distilled water, B; positive control on distilled water and C; on 100 mg/kg/day metformin groups. Diabetes mellitus (DM) was induced using streptozotocin 65 mg/kg intraperitoneally and treatments were given daily by oral gavage for 3 weeks. Plasma fasting blood glucose (FBG), kidney tissue oxidative stress markers and histology were determined.
Results: The results showed that FBG, MDA, and PCO levels were significantly higher in B group compared to A group, and lower in C group compared to B. The TAC level was significantly lower in B compared to A and higher in C compared to B group of rats. However, though histological study shows improvement in kidney histology in all treatments, kidney weight did not differ.
Conclution: The results suggest that, metformin reduces oxidative stress in streptozotocin-induced diabetic rats possibly through its antihyperglycaemic effect.

Key words: diabetes, metformin, oxidative stress, streptozotocin, kidney


 
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Pubmed Style

Usman UZ, Mohamed M, Bakar ABBA, Ishaka A. Oral Hypoglycaemic Agent Metformin Reduces Oxidative Stress and Improves Kidney Histology in Streptozotocin-induced Diabetic Rats. Nig. J. Basic Appl. Sci.. 2018; 26(2): 54-58. doi:10.4314/njbas.v26i2.8


Web Style

Usman UZ, Mohamed M, Bakar ABBA, Ishaka A. Oral Hypoglycaemic Agent Metformin Reduces Oxidative Stress and Improves Kidney Histology in Streptozotocin-induced Diabetic Rats. www.njbas-udus.com/?mno=272728 [Access: May 19, 2019]. doi:10.4314/njbas.v26i2.8


AMA (American Medical Association) Style

Usman UZ, Mohamed M, Bakar ABBA, Ishaka A. Oral Hypoglycaemic Agent Metformin Reduces Oxidative Stress and Improves Kidney Histology in Streptozotocin-induced Diabetic Rats. Nig. J. Basic Appl. Sci.. 2018; 26(2): 54-58. doi:10.4314/njbas.v26i2.8



Vancouver/ICMJE Style

Usman UZ, Mohamed M, Bakar ABBA, Ishaka A. Oral Hypoglycaemic Agent Metformin Reduces Oxidative Stress and Improves Kidney Histology in Streptozotocin-induced Diabetic Rats. Nig. J. Basic Appl. Sci.. (2018), [cited May 19, 2019]; 26(2): 54-58. doi:10.4314/njbas.v26i2.8



Harvard Style

Usman, U. Z., Mohamed, . M., Bakar, . A. B. B. A. & Ishaka, . A. (2018) Oral Hypoglycaemic Agent Metformin Reduces Oxidative Stress and Improves Kidney Histology in Streptozotocin-induced Diabetic Rats. Nig. J. Basic Appl. Sci., 26 (2), 54-58. doi:10.4314/njbas.v26i2.8



Turabian Style

Usman, Umar Zayyanu, Mahaneem Mohamed, Ainul Bhiyah Binti Abu Bakar, and Aminu Ishaka. 2018. Oral Hypoglycaemic Agent Metformin Reduces Oxidative Stress and Improves Kidney Histology in Streptozotocin-induced Diabetic Rats. Nigerian Journal of Basic and Applied Sciences, 26 (2), 54-58. doi:10.4314/njbas.v26i2.8



Chicago Style

Usman, Umar Zayyanu, Mahaneem Mohamed, Ainul Bhiyah Binti Abu Bakar, and Aminu Ishaka. "Oral Hypoglycaemic Agent Metformin Reduces Oxidative Stress and Improves Kidney Histology in Streptozotocin-induced Diabetic Rats." Nigerian Journal of Basic and Applied Sciences 26 (2018), 54-58. doi:10.4314/njbas.v26i2.8



MLA (The Modern Language Association) Style

Usman, Umar Zayyanu, Mahaneem Mohamed, Ainul Bhiyah Binti Abu Bakar, and Aminu Ishaka. "Oral Hypoglycaemic Agent Metformin Reduces Oxidative Stress and Improves Kidney Histology in Streptozotocin-induced Diabetic Rats." Nigerian Journal of Basic and Applied Sciences 26.2 (2018), 54-58. Print. doi:10.4314/njbas.v26i2.8



APA (American Psychological Association) Style

Usman, U. Z., Mohamed, . M., Bakar, . A. B. B. A. & Ishaka, . A. (2018) Oral Hypoglycaemic Agent Metformin Reduces Oxidative Stress and Improves Kidney Histology in Streptozotocin-induced Diabetic Rats. Nigerian Journal of Basic and Applied Sciences, 26 (2), 54-58. doi:10.4314/njbas.v26i2.8





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