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Phytomedical Potentials of Chromolaena Odorata Against Arsenic-Induced Testicular Toxicity In Wistar Rats

Olufunke Eunice Ola-Davies, Abimbola Adetokunbo Oloye, Samuel Olumide Ajani.

Abstract
The testicular, sperm and endocrine protective properties of Chromolaena odorata (CA) in arsenic treated rats were investigated using forty male wistar rats (190-200g) grouped into 4 (A to D) of ten rats each. Oral administrations for 2 weeks of 0.2ml corn oil (A), 2.5mg/kg of sodium arsenite (B), 200mg/kg ethanol leaf extract (ELE) of CA (C), 200mg/kg ELE of CA and 2.5mg/kg sodium arsenite given at 1 hour interval (D) were done. Twenty-four hours after final administrations, semen, blood biochemical and hormonal analysis were carried out after sacrifice of rats. Results revealed that Group C’s mean scrotal circumference, Left and Right testicular weights were highest across groups and significant compared to group B values (p<0.05). Group C had significantly (P>0.05) highest mean value of sperm motility across the groups just as group A was significantly (p<0.05) higher than those of groups B and D. Significantly low Testosterone and high luteinizing hormone concentrations were observed in group B. It was concluded in this study that ethanol leaf extract of Chromolena odorata had a profound scrotal, testicular, sperm and endocrine protective properties in arsenic-treated wistar strain albino rats and therefore could be incorporated into animal feeds especially in the chronically exposed population.

Key words: Chromolaena odorata, reproductive toxicity, arsenic,testicular,Wistar rats


 
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How to Cite this Article
Pubmed Style

Olufunke Eunice Ola-Davies, Abimbola Adetokunbo Oloye, Samuel Olumide Ajani. Phytomedical Potentials of Chromolaena Odorata Against Arsenic-Induced Testicular Toxicity In Wistar Rats. Nig. J. Basic Appl. Sci.. 2019; 27(1): 67-75. doi:10.4314/njbas.v27i1.9

Web Style

Olufunke Eunice Ola-Davies, Abimbola Adetokunbo Oloye, Samuel Olumide Ajani. Phytomedical Potentials of Chromolaena Odorata Against Arsenic-Induced Testicular Toxicity In Wistar Rats. www.njbas-udus.com/?mno=289919 [Access: January 24, 2020]. doi:10.4314/njbas.v27i1.9

AMA (American Medical Association) Style

Olufunke Eunice Ola-Davies, Abimbola Adetokunbo Oloye, Samuel Olumide Ajani. Phytomedical Potentials of Chromolaena Odorata Against Arsenic-Induced Testicular Toxicity In Wistar Rats. Nig. J. Basic Appl. Sci.. 2019; 27(1): 67-75. doi:10.4314/njbas.v27i1.9


Vancouver/ICMJE Style

Olufunke Eunice Ola-Davies, Abimbola Adetokunbo Oloye, Samuel Olumide Ajani. Phytomedical Potentials of Chromolaena Odorata Against Arsenic-Induced Testicular Toxicity In Wistar Rats. Nig. J. Basic Appl. Sci.. (2019), [cited January 24, 2020]; 27(1): 67-75. doi:10.4314/njbas.v27i1.9


Harvard Style

Olufunke Eunice Ola-Davies, Abimbola Adetokunbo Oloye, Samuel Olumide Ajani (2019) Phytomedical Potentials of Chromolaena Odorata Against Arsenic-Induced Testicular Toxicity In Wistar Rats. Nig. J. Basic Appl. Sci., 27 (1), 67-75. doi:10.4314/njbas.v27i1.9


Turabian Style

Olufunke Eunice Ola-Davies, Abimbola Adetokunbo Oloye, Samuel Olumide Ajani. 2019. Phytomedical Potentials of Chromolaena Odorata Against Arsenic-Induced Testicular Toxicity In Wistar Rats. Nigerian Journal of Basic and Applied Sciences, 27 (1), 67-75. doi:10.4314/njbas.v27i1.9


Chicago Style

Olufunke Eunice Ola-Davies, Abimbola Adetokunbo Oloye, Samuel Olumide Ajani. "Phytomedical Potentials of Chromolaena Odorata Against Arsenic-Induced Testicular Toxicity In Wistar Rats." Nigerian Journal of Basic and Applied Sciences 27 (2019), 67-75. doi:10.4314/njbas.v27i1.9


MLA (The Modern Language Association) Style

Olufunke Eunice Ola-Davies, Abimbola Adetokunbo Oloye, Samuel Olumide Ajani. "Phytomedical Potentials of Chromolaena Odorata Against Arsenic-Induced Testicular Toxicity In Wistar Rats." Nigerian Journal of Basic and Applied Sciences 27.1 (2019), 67-75. Print. doi:10.4314/njbas.v27i1.9


APA (American Psychological Association) Style

Olufunke Eunice Ola-Davies, Abimbola Adetokunbo Oloye, Samuel Olumide Ajani (2019) Phytomedical Potentials of Chromolaena Odorata Against Arsenic-Induced Testicular Toxicity In Wistar Rats. Nigerian Journal of Basic and Applied Sciences, 27 (1), 67-75. doi:10.4314/njbas.v27i1.9


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