E-ISSN 0331-8753 | ISSN 0794-5698
 

Original Research 


Antioxidant Properties of Methanolic Extracts of some Nigerian Plants on Nutritionally-Stressed Rats

ES Omoregie, AU Osagie.

Abstract
The antioxidant properties of methanolic extracts of six locally consumed plants in Nigeria were comparatively evaluated both in vitro and in vivo. The plants included V. amygdalina (bitter leaf); C. rubens (‘ebolo’); A. hybridus (‘tete’); J. tanjorensis (jatropha); G. africana (‘okazi’) and T. triangulare (water leaf). The in vitro study indicate that the DPPH radical scavenging activity was highest (p<0.05) in ebolo and water leaf. The proanthocyanidin content was significantly higher (p<0.05) in ebolo and tete. Jatropha extract has the highest phenolic content. Flavonoid content is significantly high (p<0.05) in jatropha and water leaf extracts. In vivo study of the effect of the extracts, on nutritionally stressed male albino rats, show that the liver and kidney tissues of rats fed the protein deficient diet (PDD) had significantly lower (p<0.05) superoxide dismutase (SOD), catalase (CAT), vitamin E, vitamin C levels and higher lipid peroxidation levels when compared with the control. However, supplementation of the PDD diet with the various extracts resulted in significantly higher (p<0.05) levels of SOD, CAT, vitamin E, vitamin C and reduced lipid peroxidation relative to the PDD group. Likewise, feeding of normal rats with the extracts resulted in higher levels of these parameters when compared with the control. The results suggest that the plant leaves possess varied degrees of antioxidant activity both in vitro and in vivo.

Key words: Nutritional oxidative stress, Reactive oxygen species, Antioxidant activity, Protein deficient diet, Methanolic extract


 
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Pubmed Style

ES Omoregie, AU Osagie. Antioxidant Properties of Methanolic Extracts of some Nigerian Plants on Nutritionally-Stressed Rats. Nig. J. Basic Appl. Sci.. 2012; 20(1): 7-20.


Web Style

ES Omoregie, AU Osagie. Antioxidant Properties of Methanolic Extracts of some Nigerian Plants on Nutritionally-Stressed Rats. www.njbas-udus.com/?mno=41482 [Access: July 24, 2019].


AMA (American Medical Association) Style

ES Omoregie, AU Osagie. Antioxidant Properties of Methanolic Extracts of some Nigerian Plants on Nutritionally-Stressed Rats. Nig. J. Basic Appl. Sci.. 2012; 20(1): 7-20.



Vancouver/ICMJE Style

ES Omoregie, AU Osagie. Antioxidant Properties of Methanolic Extracts of some Nigerian Plants on Nutritionally-Stressed Rats. Nig. J. Basic Appl. Sci.. (2012), [cited July 24, 2019]; 20(1): 7-20.



Harvard Style

ES Omoregie, AU Osagie (2012) Antioxidant Properties of Methanolic Extracts of some Nigerian Plants on Nutritionally-Stressed Rats. Nig. J. Basic Appl. Sci., 20 (1), 7-20.



Turabian Style

ES Omoregie, AU Osagie. 2012. Antioxidant Properties of Methanolic Extracts of some Nigerian Plants on Nutritionally-Stressed Rats. Nigerian Journal of Basic and Applied Sciences, 20 (1), 7-20.



Chicago Style

ES Omoregie, AU Osagie. "Antioxidant Properties of Methanolic Extracts of some Nigerian Plants on Nutritionally-Stressed Rats." Nigerian Journal of Basic and Applied Sciences 20 (2012), 7-20.



MLA (The Modern Language Association) Style

ES Omoregie, AU Osagie. "Antioxidant Properties of Methanolic Extracts of some Nigerian Plants on Nutritionally-Stressed Rats." Nigerian Journal of Basic and Applied Sciences 20.1 (2012), 7-20. Print.



APA (American Psychological Association) Style

ES Omoregie, AU Osagie (2012) Antioxidant Properties of Methanolic Extracts of some Nigerian Plants on Nutritionally-Stressed Rats. Nigerian Journal of Basic and Applied Sciences, 20 (1), 7-20.