E-ISSN 2756-4843 | ISSN 0794-5698
 

Original Research 


Effect of Cymbopogon citratus and Piliostigma reticulatum Aqueous Leaf Extracts on Rat Liver Function and In vitro Schizont Maturation Inhibition

O. Oderinde, A. Onu, A. Shagari and O. Olaitan.

Abstract
The most severe form of malaria is caused by the parasite Plasmodium falciparum, which undergoes antigenic variation. However, plant products continue to make an immense contribution to malaria chemotherapy. In this research, the inhibitory effect of C. citratus and P. reticulatum on schizont maturation was investigated using in vitro assay. Also effect of the extract on some enzymatic and non-enzyme liver markers was determined after subchronic oral administration to albino rat. From the result it was observed that C. citratus extract and P. reticulatum inhibited schizont formation with an IC50 of 7.25 mg/l and 3.25 mg/l respectively. The several concentrations used for this research did not significantly change the values of serum total proteins, Albumin, Total bilirubin and Conjugated bilirubin when compared with the control values. Similarly, we did not observe any significant (P < 0.05) difference in the liver enzyme markers in both plant extract tested, neither were they dose dependent. The finding of this research is a proof of concept that C. citratus and P. reticulatum extract have antimalarial activity and may be safe for the management of malaria disease.

Key words: Cymbopogon citratus , Piliostigma reticulatum, Plasmodium falciparum, Enzyme Inhibition and Toxicity.


 
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How to Cite this Article
Pubmed Style

Oderinde O, Onu A, Olaitan ASaO. Effect of Cymbopogon citratus and Piliostigma reticulatum Aqueous Leaf Extracts on Rat Liver Function and In vitro Schizont Maturation Inhibition. Nig. J. Basic Appl. Sci.. 2021; 29(2): 1-8. doi:10.4314/njbas.v29i2.1


Web Style

Oderinde O, Onu A, Olaitan ASaO. Effect of Cymbopogon citratus and Piliostigma reticulatum Aqueous Leaf Extracts on Rat Liver Function and In vitro Schizont Maturation Inhibition. https://www.njbas-udus.com/?mno=41612 [Access: April 05, 2022]. doi:10.4314/njbas.v29i2.1


AMA (American Medical Association) Style

Oderinde O, Onu A, Olaitan ASaO. Effect of Cymbopogon citratus and Piliostigma reticulatum Aqueous Leaf Extracts on Rat Liver Function and In vitro Schizont Maturation Inhibition. Nig. J. Basic Appl. Sci.. 2021; 29(2): 1-8. doi:10.4314/njbas.v29i2.1



Vancouver/ICMJE Style

Oderinde O, Onu A, Olaitan ASaO. Effect of Cymbopogon citratus and Piliostigma reticulatum Aqueous Leaf Extracts on Rat Liver Function and In vitro Schizont Maturation Inhibition. Nig. J. Basic Appl. Sci.. (2021), [cited April 05, 2022]; 29(2): 1-8. doi:10.4314/njbas.v29i2.1



Harvard Style

Oderinde, O., Onu, . A. & Olaitan, . A. S. a. O. (2021) Effect of Cymbopogon citratus and Piliostigma reticulatum Aqueous Leaf Extracts on Rat Liver Function and In vitro Schizont Maturation Inhibition. Nig. J. Basic Appl. Sci., 29 (2), 1-8. doi:10.4314/njbas.v29i2.1



Turabian Style

Oderinde, O., A. Onu, and A. Shagari and O. Olaitan. 2021. Effect of Cymbopogon citratus and Piliostigma reticulatum Aqueous Leaf Extracts on Rat Liver Function and In vitro Schizont Maturation Inhibition. Nigerian Journal of Basic and Applied Sciences, 29 (2), 1-8. doi:10.4314/njbas.v29i2.1



Chicago Style

Oderinde, O., A. Onu, and A. Shagari and O. Olaitan. "Effect of Cymbopogon citratus and Piliostigma reticulatum Aqueous Leaf Extracts on Rat Liver Function and In vitro Schizont Maturation Inhibition." Nigerian Journal of Basic and Applied Sciences 29 (2021), 1-8. doi:10.4314/njbas.v29i2.1



MLA (The Modern Language Association) Style

Oderinde, O., A. Onu, and A. Shagari and O. Olaitan. "Effect of Cymbopogon citratus and Piliostigma reticulatum Aqueous Leaf Extracts on Rat Liver Function and In vitro Schizont Maturation Inhibition." Nigerian Journal of Basic and Applied Sciences 29.2 (2021), 1-8. Print. doi:10.4314/njbas.v29i2.1



APA (American Psychological Association) Style

Oderinde, O., Onu, . A. & Olaitan, . A. S. a. O. (2021) Effect of Cymbopogon citratus and Piliostigma reticulatum Aqueous Leaf Extracts on Rat Liver Function and In vitro Schizont Maturation Inhibition. Nigerian Journal of Basic and Applied Sciences, 29 (2), 1-8. doi:10.4314/njbas.v29i2.1





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