E-ISSN 0331-8753 | ISSN 0794-5698
 
2019, Vol: 27, Issue: 2
27 / 2Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Original Research 


Expression of Wild-Type p53 by Curcumin, Alpinetin and Flavokawain B in Colorectal Cancer cells Expressing R273H Mutant p53

I. Malami, A. Muhammad, I. B. Abubakar and A. M. Alhassan.

Abstract
A mutation in p53 is frequently reported in nearly 50% of all of human cancers arising from DNA-binding core domain of p53. DNA-contact mutant R273H rendered p53 at dysfunctional state due to the substitution of single residue Arg273 for His273. Here, natural bioactive compounds curcumin, alpinetin and flavokawain B were investigated for possible stabilisation of wild-type p53 expression in vitro using HT-29 cells harbouring R273H rendered p53. Accordingly, all the bioactive compounds were able to induce the expression of wild-type p53 both at the levels of gene and protein expression. A dose dependent induction of p53 was evident at 12.5, 25 and 50 µM concentration. The present study have substantiate evidences that the bioactive compounds may have restored the wild-type p53 functional activity in tumour cells expressing R273H mutant p53.

Key words: Curcumin, Alpinetin, Flavokawain B, p53, R273H


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by I. Malami
Articles by A. Muhammad
Articles by I. B. Abubakar and A. M. Alhassan
on Google
on Google Scholar
Article Statistics
 Viewed: 999
Downloaded: 2


How to Cite this Article
Pubmed Style

Malami I, Muhammad A, . Expression of Wild-Type p53 by Curcumin, Alpinetin and Flavokawain B in Colorectal Cancer cells Expressing R273H Mutant p53. Nig. J. Basic Appl. Sci.. 2019; 27(2): 88-94. doi:10.4314/njbas.v27i2.12

Web Style

Malami I, Muhammad A, . Expression of Wild-Type p53 by Curcumin, Alpinetin and Flavokawain B in Colorectal Cancer cells Expressing R273H Mutant p53. http://www.njbas-udus.com/?mno=42251 [Access: March 28, 2020]. doi:10.4314/njbas.v27i2.12

AMA (American Medical Association) Style

Malami I, Muhammad A, . Expression of Wild-Type p53 by Curcumin, Alpinetin and Flavokawain B in Colorectal Cancer cells Expressing R273H Mutant p53. Nig. J. Basic Appl. Sci.. 2019; 27(2): 88-94. doi:10.4314/njbas.v27i2.12


Vancouver/ICMJE Style

Malami I, Muhammad A, . Expression of Wild-Type p53 by Curcumin, Alpinetin and Flavokawain B in Colorectal Cancer cells Expressing R273H Mutant p53. Nig. J. Basic Appl. Sci.. (2019), [cited March 28, 2020]; 27(2): 88-94. doi:10.4314/njbas.v27i2.12


Harvard Style

Malami, I., Muhammad, . A. & (2019) Expression of Wild-Type p53 by Curcumin, Alpinetin and Flavokawain B in Colorectal Cancer cells Expressing R273H Mutant p53. Nig. J. Basic Appl. Sci., 27 (2), 88-94. doi:10.4314/njbas.v27i2.12


Turabian Style

Malami, I., A. Muhammad, and I. B. Abubakar and A. M. Alhassan. 2019. Expression of Wild-Type p53 by Curcumin, Alpinetin and Flavokawain B in Colorectal Cancer cells Expressing R273H Mutant p53. Nigerian Journal of Basic and Applied Sciences, 27 (2), 88-94. doi:10.4314/njbas.v27i2.12


Chicago Style

Malami, I., A. Muhammad, and I. B. Abubakar and A. M. Alhassan. "Expression of Wild-Type p53 by Curcumin, Alpinetin and Flavokawain B in Colorectal Cancer cells Expressing R273H Mutant p53." Nigerian Journal of Basic and Applied Sciences 27 (2019), 88-94. doi:10.4314/njbas.v27i2.12


MLA (The Modern Language Association) Style

Malami, I., A. Muhammad, and I. B. Abubakar and A. M. Alhassan. "Expression of Wild-Type p53 by Curcumin, Alpinetin and Flavokawain B in Colorectal Cancer cells Expressing R273H Mutant p53." Nigerian Journal of Basic and Applied Sciences 27.2 (2019), 88-94. Print. doi:10.4314/njbas.v27i2.12


APA (American Psychological Association) Style

Malami, I., Muhammad, . A. & (2019) Expression of Wild-Type p53 by Curcumin, Alpinetin and Flavokawain B in Colorectal Cancer cells Expressing R273H Mutant p53. Nigerian Journal of Basic and Applied Sciences, 27 (2), 88-94. doi:10.4314/njbas.v27i2.12




Most Viewed Articles
  • Isolation and Identification of Fungi Associated with the Spoilage of Sweet Orange (Citrus Sinensis) Fruits In Sokoto State
    I.Y. Tafinta, K.Shehu, H. Abdulganiyyu, A.M. Rabe and A. Usman
    Nig. J. Basic Appl. Sci.. 2013; 21(3): 193-196
    » Abstract & References

  • Heavy Metals and Physicochemical Properties of Soils in Kano Urban Agricultural Lands
    U.M. Dawaki, A.U. Dikko, S.S. Noma and U. Aliyu
    Nig. J. Basic Appl. Sci.. 2013; 21(3): 239-246
    » Abstract & References

  • Study on Biochemical Indices of Liver Function Tests of Albino Rats Supplemented with Three Sources of Vegetable Oils [English]
    K.E. Imafidon and L.O. Okunrobo
    Nig. J. Basic Appl. Sci.. 2012; 20(2): 105-110
    » Abstract

  • Effect of Sources of Organic Manure on Growth and Yields of Okra (Abelmoschus esculentus L.) in Sokoto, Nigeria [English]
    R.A. Tiamiyu, H.G. Ahmed and A.S. Muhammad
    Nig. J. Basic Appl. Sci.. 2012; 20(3): 213-216
    » Abstract

  • Optimum Temperature and Thermal Stability of Crude Polyphenol Oxidase from some Common Fruits
    AB Bello, MS Sule
    Nig. J. Basic Appl. Sci.. 2012; 20(1): 27-31
    » Abstract

    • Most Downloaded
  • Isolation and Identification of Fungi Associated with the Spoilage of Sweet Orange (Citrus Sinensis) Fruits In Sokoto State
    I.Y. Tafinta, K.Shehu, H. Abdulganiyyu, A.M. Rabe and A. Usman
    Nig. J. Basic Appl. Sci.. 2013; 21(3): 193-196
    » Abstract & References

  • Optimization of Steam Distillation of Essential Oil of Eucalyptus tereticornis by Response Surface Methodology [English]
    M.S. Galadima, A.S. Ahmed, A.S. Olawale and I. M. Bugaje
    Nig. J. Basic Appl. Sci.. 2012; 20(4): 368-372
    » Abstract

  • Biogas production through Co-digestion of palm oil mill effluent with cow manure
    Umar Hayatu Sidik, Firdausi Bin Razali, Sharifah Rafidah Wan Alwi, Fadimtu Maigari
    Nig. J. Basic Appl. Sci.. 2013; 21(1): 79-84
    » Abstract

  • The Swelling Behaviour of Polystyrene (PS)/ Polyvinylacetate (Pvac) Blends in Different Solvents and the Effects of -Cellulose used as Filler on the Electrical Conductivity. [English]
    P. A. P. Mamza and B.T. Nwufo
    Nig. J. Basic Appl. Sci.. 2008; 16(2): 165 -
    » Abstract

  • Characterization and Classification of Soils on an Agricultural landscape in Dingyadi District, Sokoto State, Nigeria
    M.B. Sharu, M. Yakubu, S.S. Noma and A.I.Tsafe
    Nig. J. Basic Appl. Sci.. 2013; 21(2): 137 -147
    » Abstract

    • Most Cited Articles
    This is an open access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles in this journal without asking prior permission from the publisher or the author. This is in accordance with the Budapest Open Access Initiative (BOAI) definition of open access.
    The articles in Nigerian Journal of Basic and Applied Sciences are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
    Copyright © 2020 Nigerian Journal of Basic and Applied Sciences All Rights Reserved. Subject to change without notice from or liability to Nigerian Journal of Basic and Applied Sciences.
    For best results, please use Internet Explorer or Google Chrome

    Contact Information


    Nigerian Journal of Basic and Applied Sciences (NJBAS)

    Usmanu Danfodiyo University, Sokoto, Nigeria

    P.M.B. 2346, Sokoto

    email: njbas@udusok.edu.ng

    Mobile contact:+2348057937555

     

     
    POLICIES & JOURNAL LINKS
    Author Login
    Reviewer Login
    About Publisher
    Advertising Policy
    Author's Rights and Obligations
    Conflict of Interest Policy
    Editorial Policies
    Peer Review Policy
    Editorial & Peer Review Process
    Editorial & Peer Review Process
    License Information
    Plagiarism Policy
    Privacy Policy
    Protection of Research Participants (Statement On Human And Animal Rights)
    Publishing Ethics
    Corrections, Retractions & Expressions of Concern
    Self-Archiving Policies
    Statement of Informed Consent
    Terms of Use