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Effect of Camel Milk’s Supplementation on Serum Glucose Levels, Lipid Profile and Body Weight of Alloxan-Induced Diabetic Rats

S.A. Isa, K.G. Ibrahim and I. Abubakar.

Abstract
Cases of diabetes are on the rise in almost every population and epidemiological studies suggest that without proper prevention and control measures, prevalence of the disease will continue to increase globally. The aim of the current study was to investigate the effect of camel milk supplementation on serum glucose, lipid profile and body weight of alloxan-induced diabetic rats. Rats were rendered diabetic by intravenous injection of alloxan (80mg/kg body weight). Diabetic rats showed significantly higer blood glucose levels (9.68±1.36 mmol/L). Treatment with camel milk significantly decreases blood glucose levels (5.33±0.46) p<0.05 compared to control. There was a significant increase (p<0.05) in serum total cholesterol, triglyceride, low density lipoprotein cholesterol, very low density lipoprotein cholesterol, and a significant decrease (p<0.05) in high density lipoprotein cholesterol in diabetic untreated rats as compared with control group. However, a significant decrease (p<0.05) in total cholesterol, triglyceride, low density lipoprotein cholesterol, very low density lipoprotein cholesterol, and a significant increase (p<0.05) in high density lipoprotein cholesterol was observed in diabetic treated with camel milk group as compared with diabetic untreated group. No significant change in body weights were observed in all experimental groups during the period of the experiment. The current study demonstrates the efficacy of camel milk in management of diabetes in alloxan induced diabetic rats. This suggests that camel milk may have important implication in the management of diabetes. Further studies are required to elucidate the safety as well as the mechanism of action.

Key words: Camel Milk, Serum glucose, Lipid profile, Diabetes


 
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REFERENCES
Abbott, R.D., Wilson, P.W., Kannel, W.B. and Castelli, W.P. (1988).High density lipoprotein cholesterol, total cholesterol screening and myocardial infarction. The Framingham study. Atherosclerosis, 8: 207-211.
Agrawal, R.P., Beniwal, R., Sharma, S., Kochar, D.K., Tuteja, F.C. and Ghorui, S.K (2005). Camel milk as an adjunct to insulin therapy improves longterm glycemic control and reduction in doses of insulin in patients with type-1 diabetes &#8211; a 1 year randomized controlled trial. Diabetes Research Clinical Practice 68:176&#8211;177.
Agrawal, R.P., Swami, S.C. and Beniwal, R. (2003). Effect of camel milk on glycemic control, risk factors and diabetes quality of life in type 1 diabetes: A randomized prospective controlled study. Journal Camel Practice Research, 10(1):45-50.
Alberti, K.G., Zimmet P. and Shaw, J. (2007). International Diabetes Federation: A Consensus on Type 2 Diabetes Prevention. DiabeteMedicine, 24(5): 451-463
Allain,C.C., Poon, L.S., Chan, C.S.G., Richmond, W. and Fu, P.C. (1974). Enzymatic determination of total serum cholesterol. Clinical Chemistry, 20: 470 [Pubmed]   
Arkkila, P.E., Koskinen, P.J. and Kantola, I.M. (2001). Diabetic complications are associated with liver enzyme activities in people with type I diabetes. Diabetes. Research Clinical Practice, 52: 113-118. [DOI via Crossref]   
Balku, B., Hu, G., Qiao, Q., Tuomilehto, J., BorchJohnsen, K. and Pyoraja, K. (2004). Prediction of the Risk of Cardiovascular Mortality Using a Score that Includes Glucose as a risk factor.The DECODE study. Diabetologia, 47(12):2118-2128. [DOI via Crossref]    [Pubmed]   
Black, H.E., Rosenblum, I.Y. and Capen, C.C. (1980).Chemically induced (streptozotocin-alloxan) diabetes mellitus in the dog. Biochemical and ultrastructural studies. American Journal of. Pathology, 98: 295-310. [Pubmed]   
Burstein, M., Scholnick, H.R. and Morfin, R. (1970).Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions. Journal of Lipid Research, 11: 583-595. [Pubmed]   
Davis, W.A., Knuiman, M.W., Hendrie, D. and Davis,T.M. (2006). The Obesity Driven Rising Costs of Type 2 Diabetes in Australia: Projections Fromthe Fremantle Diabetes Study. Internal MedicineJournal, 36(3):151-161. [DOI via Crossref]    [Pubmed]   
Farah, Z. (1993). Composition and characteristics of camel milk. Journal of Dairy Research, 60: 603-626. [DOI via Crossref]    [Pubmed]   
Farah, Z., Rettenmaier, R. and Atkins, D. (1992). Vitamin content of camel milk". International Journal for Vitamin and Nutrition Research, 62(1): 30&#8211;33.
Goldstein, B.J. (2003). Insulin Resistance: From Benign to type 2 diabetes mellitus. ReviewCardiovascular Medicine, 4(Suppl 6): S3-S10
Friedewald, W.T., Levy, R.I. and Fredrickson, D.S. (1972). Estimation of LDL-C in plasma without the use of the preparative ultracentrifuge.Clinical Chemistry, 18(6): 499-502 [Pubmed]   
Hassan, N.S. and Emam, M.A. (2012). Protective Effect of Camel Milk and Ginkgo biloba Extract Against Alloxan-Induced Diabetes in Rats. Journal Diabetes Metabolism 3: 231. [DOI via Crossref]    [DOI via Crossref]   
Hsueh, W.A. and Law, R.E. (2001). PPAR&#947; and Arteriosclerosis: Effect on Cell Growth and Movement. Arterioscler. Thrombosis VascularBiology, 21(12):1891-1895 [DOI via Crossref]   
International Diabetes Federation (IDF) 2009. The IDF Consensus worldwide definition of the metabolic syndrome. Available at: http://www.diabetesvoice.org/files/attachments/article_361_en.pdf
Lebovitz, H.E., and Banerji, M.A. (2001). Insulin Resistance and its Treatment by Thiazolidinediones. Recent. Progress. Hormone Research, 56: 265-294 [DOI via Crossref]    [Pubmed]   
Malik, S.Y.H., Sana, I.G. and Richard, K.R.(2008).Seasonal variations in the chemical composition of camel milk in Jordan. Journal of Dairy Research, 75: 8&#8211;12.
MathĂ© D (1995) Dyslipidemia and diabetes: animal models. Diabete Metabolism, 21: 106-111. [Pubmed]   
Muoio, D.M. and Newgard, C.B (2008). Molecular and metabolic mechamism of insulin resistance and B-cell failure in types 2 diabetes. Nature Review Molecular Cell Biology, 9: 193-205. [DOI via Crossref]    [Pubmed]   
Nissen SE, Wolski K (2007). Effect of Rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. New EnglandJournal Medicine, 356(24): 2457-2471. [DOI via Crossref]    [Pubmed]   
Rader, D. J. (2006). Molecular regulation of HDL metabolism and function: implications for novel therapies. Journal Clinical Investigation, 116:3090-3100. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
Renup, C.C. (1970). drugs producing diabetes through damage of the insulin secreting cells.Pharmcology Review, 22: 485-518.
Sboui A., Djegham M., Khorchani T., Mohamed Hammadi M., Barhoumi K, Omrane Belhadj O (2010). Effect of camel milk on blood glucose, cholesterol and total proteins variations in alloxan-induced diabetic dogs InternationalJournal Diabetes and Metabolism, 18:5-11.
Sakudelski, T (2001). Mechanism of alloxan and streptozocin action in beta cells of the rat pancreas. Physiological Research, 50(6): 536-546.
Shabo, Y. R. Barzel, M. Margoulis and R. yagil, (2005). Camel milk for food allergies in children. Israel. Medical Association. Journal, 7: 796-798. [Pubmed]   
Stemerman, M. B. (2000). Lipoprotein effects on the vessel wall. Circulation Research, 86, 715-6. Lipoprotein effects on the vessel wall. [DOI via Crossref]    [Pubmed]   
Trinder, P. (1969). Determination of blood glucose in blood using glucose oxidase with an alternative oxygen acceptor, Annals of ClinicalBiochemistry, 6: 24-25.
Tietz, N.W. (1990). Serum triglyceride determination. In: Clinical guide to laboratory tests, second edition, W.B. Saunders Co, Philadelphia, USA, Pp 554-556
Tiwari, R.I., Singh, V. And Barthwal, M.K. (2008). Macrophages: An Elucive Yet emerging Therapeutic Targets of Atherosclerosis. Medicinal Research Reviews, 28(4): 483-544. [DOI via Crossref]    [Pubmed]   
Typerg, B, Anderson A, Hakan Borgla (2001). Species differences in susceptibility of transplanted and cultured pancreatic islets to the B-cell. General Comparative Endocrinology. 122: 238-251. [DOI via Crossref]    [Pubmed]   
van Herpen NA, Schrauwen-Hinderling VB (2008). Lipid Accumulation in Non-adipose Tissue and Lipotoxicity. Physiology and Behavior,94(2):231-241. [DOI via Crossref]    [Pubmed]   
World Health Organization (WHO) (2006). Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia: report of a WHO/IDF consultation. Geneva: p. 21.
Yach D, Stuckler D, Brownell KD (2006). Epidemiologic and Economic Consequences of the Global Epidemics of Obesity and Diabetes.Nature Medicine, 12(1):62-66. [DOI via Crossref]    [Pubmed]   

How to Cite this Article
Pubmed Style

S.A. Isa, K.G. Ibrahim and I. Abubakar. Effect of Camel Milk’s Supplementation on Serum Glucose Levels, Lipid Profile and Body Weight of Alloxan-Induced Diabetic Rats. Nig. J. Basic Appl. Sci.. 2013; 21(3): 187-192.


Web Style

S.A. Isa, K.G. Ibrahim and I. Abubakar. Effect of Camel Milk’s Supplementation on Serum Glucose Levels, Lipid Profile and Body Weight of Alloxan-Induced Diabetic Rats. www.njbas-udus.com/?mno=48089 [Access: June 20, 2019].


AMA (American Medical Association) Style

S.A. Isa, K.G. Ibrahim and I. Abubakar. Effect of Camel Milk’s Supplementation on Serum Glucose Levels, Lipid Profile and Body Weight of Alloxan-Induced Diabetic Rats. Nig. J. Basic Appl. Sci.. 2013; 21(3): 187-192.



Vancouver/ICMJE Style

S.A. Isa, K.G. Ibrahim and I. Abubakar. Effect of Camel Milk’s Supplementation on Serum Glucose Levels, Lipid Profile and Body Weight of Alloxan-Induced Diabetic Rats. Nig. J. Basic Appl. Sci.. (2013), [cited June 20, 2019]; 21(3): 187-192.



Harvard Style

S.A. Isa, K.G. Ibrahim and I. Abubakar (2013) Effect of Camel Milk’s Supplementation on Serum Glucose Levels, Lipid Profile and Body Weight of Alloxan-Induced Diabetic Rats. Nig. J. Basic Appl. Sci., 21 (3), 187-192.



Turabian Style

S.A. Isa, K.G. Ibrahim and I. Abubakar. 2013. Effect of Camel Milk’s Supplementation on Serum Glucose Levels, Lipid Profile and Body Weight of Alloxan-Induced Diabetic Rats. Nigerian Journal of Basic and Applied Sciences, 21 (3), 187-192.



Chicago Style

S.A. Isa, K.G. Ibrahim and I. Abubakar. "Effect of Camel Milk’s Supplementation on Serum Glucose Levels, Lipid Profile and Body Weight of Alloxan-Induced Diabetic Rats." Nigerian Journal of Basic and Applied Sciences 21 (2013), 187-192.



MLA (The Modern Language Association) Style

S.A. Isa, K.G. Ibrahim and I. Abubakar. "Effect of Camel Milk’s Supplementation on Serum Glucose Levels, Lipid Profile and Body Weight of Alloxan-Induced Diabetic Rats." Nigerian Journal of Basic and Applied Sciences 21.3 (2013), 187-192. Print.



APA (American Psychological Association) Style

S.A. Isa, K.G. Ibrahim and I. Abubakar (2013) Effect of Camel Milk’s Supplementation on Serum Glucose Levels, Lipid Profile and Body Weight of Alloxan-Induced Diabetic Rats. Nigerian Journal of Basic and Applied Sciences, 21 (3), 187-192.








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