E-ISSN 2756-4843 | ISSN 0794-5698
 

Original Research 


Evaluation of an Antimalarial Herbal Recipe and its Individual Plant Extracts for DNA Fragmentation and Clastogenicity Potential in Swiss Albino Mice

A. Akinboro, M. A. Rufai, R. A. Adeagbo, A. O. Akanbi, A. S. Ogunkola, D. O. Okunola, T. D. Adeyeye and Y. R. Akanbi.

Abstract
In this study, water extract of leaves of Azadirachta indica and stem – bark of Alstonia boonei, and their recipe were evaluated at 25.0%, 50.0% and 100.0% following DNA fragmentation and micronucleus assays in Swiss albino mice. Distilled water and 0.05% sodium azide served as negative and positive controls, respectively. The level of superoxide dismutase, catalase and Malondialdehyde in the treated mice were determined. The FTIR technique was adopted to elucidate the functional groups of phytochemicals present, and the proximate constituents were also determined. The extract of A. indica and A. boonei except for the recipe was not significantly mutagenic compared to the controls. Water extract of A. indica had the least clastogenic activity, while A. boonei extract was most cytotoxic towards erythrocytes proliferation. Superoxide dismutase and catalase activity of the extracts and recipe was dose dependent, however, recipe at 100.0% recorded best activity. A. indica extract best suppressed generation of malondialdehyde. The phytochemicals in the extract and recipe contained hydroxyl and carbonyl functional groups, and their proximate constituents were almost the same except for the crude protein and fiber of the recipe. Conclusively, extract of A. indica caused lower cyto-muta-genotoxicity than the extract of A. boonei and recipe.

Key words: Azadirachta indica, Alstonia boonei, DNA fragmentation, Micronucleus, Recipe,


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by A. Akinboro
Articles by M. A. Rufai
Articles by R. A. Adeagbo
Articles by A. O. Akanbi
Articles by A. S. Ogunkola
Articles by D. O. Okunola
Articles by T. D. Adeyeye and Y. R. Akanbi
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Akinboro A, Rufai MA, Adeagbo RA, Akanbi AO, Ogunkola AS, Okunola DO, . Evaluation of an Antimalarial Herbal Recipe and its Individual Plant Extracts for DNA Fragmentation and Clastogenicity Potential in Swiss Albino Mice. Nig. J. Basic Appl. Sci.. 2021; 29(2): 89-101. doi:10.4314/njbas.v29i2.9


Web Style

Akinboro A, Rufai MA, Adeagbo RA, Akanbi AO, Ogunkola AS, Okunola DO, . Evaluation of an Antimalarial Herbal Recipe and its Individual Plant Extracts for DNA Fragmentation and Clastogenicity Potential in Swiss Albino Mice. https://www.njbas-udus.com/?mno=92235 [Access: April 05, 2022]. doi:10.4314/njbas.v29i2.9


AMA (American Medical Association) Style

Akinboro A, Rufai MA, Adeagbo RA, Akanbi AO, Ogunkola AS, Okunola DO, . Evaluation of an Antimalarial Herbal Recipe and its Individual Plant Extracts for DNA Fragmentation and Clastogenicity Potential in Swiss Albino Mice. Nig. J. Basic Appl. Sci.. 2021; 29(2): 89-101. doi:10.4314/njbas.v29i2.9



Vancouver/ICMJE Style

Akinboro A, Rufai MA, Adeagbo RA, Akanbi AO, Ogunkola AS, Okunola DO, . Evaluation of an Antimalarial Herbal Recipe and its Individual Plant Extracts for DNA Fragmentation and Clastogenicity Potential in Swiss Albino Mice. Nig. J. Basic Appl. Sci.. (2021), [cited April 05, 2022]; 29(2): 89-101. doi:10.4314/njbas.v29i2.9



Harvard Style

Akinboro, A., Rufai, . M. A., Adeagbo, . R. A., Akanbi, . A. O., Ogunkola, . A. S., Okunola, . D. O. & (2021) Evaluation of an Antimalarial Herbal Recipe and its Individual Plant Extracts for DNA Fragmentation and Clastogenicity Potential in Swiss Albino Mice. Nig. J. Basic Appl. Sci., 29 (2), 89-101. doi:10.4314/njbas.v29i2.9



Turabian Style

Akinboro, A., M. A. Rufai, R. A. Adeagbo, A. O. Akanbi, A. S. Ogunkola, D. O. Okunola, and T. D. Adeyeye and Y. R. Akanbi. 2021. Evaluation of an Antimalarial Herbal Recipe and its Individual Plant Extracts for DNA Fragmentation and Clastogenicity Potential in Swiss Albino Mice. Nigerian Journal of Basic and Applied Sciences, 29 (2), 89-101. doi:10.4314/njbas.v29i2.9



Chicago Style

Akinboro, A., M. A. Rufai, R. A. Adeagbo, A. O. Akanbi, A. S. Ogunkola, D. O. Okunola, and T. D. Adeyeye and Y. R. Akanbi. "Evaluation of an Antimalarial Herbal Recipe and its Individual Plant Extracts for DNA Fragmentation and Clastogenicity Potential in Swiss Albino Mice." Nigerian Journal of Basic and Applied Sciences 29 (2021), 89-101. doi:10.4314/njbas.v29i2.9



MLA (The Modern Language Association) Style

Akinboro, A., M. A. Rufai, R. A. Adeagbo, A. O. Akanbi, A. S. Ogunkola, D. O. Okunola, and T. D. Adeyeye and Y. R. Akanbi. "Evaluation of an Antimalarial Herbal Recipe and its Individual Plant Extracts for DNA Fragmentation and Clastogenicity Potential in Swiss Albino Mice." Nigerian Journal of Basic and Applied Sciences 29.2 (2021), 89-101. Print. doi:10.4314/njbas.v29i2.9



APA (American Psychological Association) Style

Akinboro, A., Rufai, . M. A., Adeagbo, . R. A., Akanbi, . A. O., Ogunkola, . A. S., Okunola, . D. O. & (2021) Evaluation of an Antimalarial Herbal Recipe and its Individual Plant Extracts for DNA Fragmentation and Clastogenicity Potential in Swiss Albino Mice. Nigerian Journal of Basic and Applied Sciences, 29 (2), 89-101. doi:10.4314/njbas.v29i2.9





Most Viewed Articles
  • Isolation and Identification of Fungi Associated with the Spoilage of Sweet Orange (Citrus Sinensis) Fruits In Sokoto State
    I.Y. Tafinta, K.Shehu, H. Abdulganiyyu, A.M. Rabe and A. Usman
    Nig. J. Basic Appl. Sci.. 2013; 21(3): 193-196
    » Abstract & References

  • Heavy Metals and Physicochemical Properties of Soils in Kano Urban Agricultural Lands
    U.M. Dawaki, A.U. Dikko, S.S. Noma and U. Aliyu
    Nig. J. Basic Appl. Sci.. 2013; 21(3): 239-246
    » Abstract & References

  • Study on Biochemical Indices of Liver Function Tests of Albino Rats Supplemented with Three Sources of Vegetable Oils [English]
    K.E. Imafidon and L.O. Okunrobo
    Nig. J. Basic Appl. Sci.. 2012; 20(2): 105-110
    » Abstract

  • Effect of Sources of Organic Manure on Growth and Yields of Okra (Abelmoschus esculentus L.) in Sokoto, Nigeria [English]
    R.A. Tiamiyu, H.G. Ahmed and A.S. Muhammad
    Nig. J. Basic Appl. Sci.. 2012; 20(3): 213-216
    » Abstract

  • Optimum Temperature and Thermal Stability of Crude Polyphenol Oxidase from some Common Fruits
    AB Bello, MS Sule
    Nig. J. Basic Appl. Sci.. 2012; 20(1): 27-31
    » Abstract

  • Most Downloaded
  • The Swelling Behaviour of Polystyrene (PS)/ Polyvinylacetate (Pvac) Blends in Different Solvents and the Effects of -Cellulose used as Filler on the Electrical Conductivity. [English]
    P. A. P. Mamza and B.T. Nwufo
    Nig. J. Basic Appl. Sci.. 2008; 16(2): 165 -
    » Abstract

  • Optimization of Steam Distillation of Essential Oil of Eucalyptus tereticornis by Response Surface Methodology [English]
    M.S. Galadima, A.S. Ahmed, A.S. Olawale and I. M. Bugaje
    Nig. J. Basic Appl. Sci.. 2012; 20(4): 368-372
    » Abstract

  • Isolation and Identification of Fungi Associated with the Spoilage of Sweet Orange (Citrus Sinensis) Fruits In Sokoto State
    I.Y. Tafinta, K.Shehu, H. Abdulganiyyu, A.M. Rabe and A. Usman
    Nig. J. Basic Appl. Sci.. 2013; 21(3): 193-196
    » Abstract & References

  • Characterization and Classification of Soils on an Agricultural landscape in Dingyadi District, Sokoto State, Nigeria
    M.B. Sharu, M. Yakubu, S.S. Noma and A.I.Tsafe
    Nig. J. Basic Appl. Sci.. 2013; 21(2): 137 -147
    » Abstract

  • Biogas production through Co-digestion of palm oil mill effluent with cow manure
    Umar Hayatu Sidik, Firdausi Bin Razali, Sharifah Rafidah Wan Alwi, Fadimtu Maigari
    Nig. J. Basic Appl. Sci.. 2013; 21(1): 79-84
    » Abstract

  • Most Cited Articles