Clinicopathological Parameters and Sialyltransferase Activity in Trypanosoma Congolense-Infected Sheep

Y. S. Baraya; M. E. Sadiq; J. A. Atata; S. J. Enam; S. Adamu; K. B. Kadima; N. M. Useh
and K. A. N. Esievo

doi:10.4314/njbas.v29i2.10

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Nig. J. Basic Appl. Sci.. 2021; 29(2): 102-111

doi: 10.4314/njbas.v29i2.10

Clinicopathological Parameters and Sialyltransferase Activity in Trypanosoma Congolense-Infected Sheep

Y. S. Baraya, M. E. Sadiq, J. A. Atata, S. J. Enam, S. Adamu, K. B. Kadima, N. M. Useh and K. A. N. Esievo.

Abstract
Cleavage of erythrocyte surface sialic acid (SA) by the sialidase produced by trypanosomes is implicated in the pathogenesis of anaemia in African animal trypanosomiasis (AAT). Sialyltransferase (ST) is believed to mediate the attachment of SA to cell surface glycoproteins and glycolipids of the desialylated erythrocytes. ST activities in Trypanosoma congolense-infected sheep and control group were investigated and their variations in physio-biochemical properties were evaluated. Six (6) apparently healthy Nigerian Yankassa breed of sheep comprising of T. congolense-infected (n=3) and non-infected (n=3) groups were used for the experiment. Parasitaemia and packed cell volume (PCV) were determined daily over a 5-week period. ST from the thyroid gland was isolated and partially purified and the enzyme kinetics was also evaluated. Anaemia (mean PCV= 18.83±0.71%) was observed in the T. congolense-infected sheep when compared with the non-infected control group (mean PCV 39.75±0.35%) and the reduction in mean PCV was significant (P<0.05). Similarly, there were variations in the physio-biochemical (e.g. pH, temperature, activation energy) properties of the ST from the T. congolense-infected and control sheep. This finding is believed to have been the response from the parasites activity in the challenged group which could be exploited further in the future control of AAT.

Key words: Anaemia, Sialic acid, Sialyltransferase, Sheep, Trypanosoma congolense

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Pubmed Style

Baraya YS, Sadiq ME, Atata JA, Enam SJ, Adamu S, Kadima KB, . Clinicopathological Parameters and Sialyltransferase Activity in Trypanosoma Congolense-Infected Sheep. Nig. J. Basic Appl. Sci.. 2021; 29(2): 102-111. doi:10.4314/njbas.v29i2.10

Web Style

Baraya YS, Sadiq ME, Atata JA, Enam SJ, Adamu S, Kadima KB, . Clinicopathological Parameters and Sialyltransferase Activity in Trypanosoma Congolense-Infected Sheep. https://www.njbas-udus.com/?mno=123496 [Access: September 15, 2023]. doi:10.4314/njbas.v29i2.10

AMA (American Medical Association) Style

Baraya YS, Sadiq ME, Atata JA, Enam SJ, Adamu S, Kadima KB, . Clinicopathological Parameters and Sialyltransferase Activity in Trypanosoma Congolense-Infected Sheep. Nig. J. Basic Appl. Sci.. 2021; 29(2): 102-111. doi:10.4314/njbas.v29i2.10

Vancouver/ICMJE Style

Baraya YS, Sadiq ME, Atata JA, Enam SJ, Adamu S, Kadima KB, . Clinicopathological Parameters and Sialyltransferase Activity in Trypanosoma Congolense-Infected Sheep. Nig. J. Basic Appl. Sci.. (2021), [cited September 15, 2023]; 29(2): 102-111. doi:10.4314/njbas.v29i2.10

Harvard Style

Baraya, Y. S., Sadiq, . M. E., Atata, . J. A., Enam, . S. J., Adamu, . S., Kadima, . K. B. & (2021) Clinicopathological Parameters and Sialyltransferase Activity in Trypanosoma Congolense-Infected Sheep. Nig. J. Basic Appl. Sci., 29 (2), 102-111. doi:10.4314/njbas.v29i2.10

Turabian Style

Baraya, Y. S., M. E. Sadiq, J. A. Atata, S. J. Enam, S. Adamu, K. B. Kadima, and N. M. Useh and K. A. N. Esievo. 2021. Clinicopathological Parameters and Sialyltransferase Activity in Trypanosoma Congolense-Infected Sheep. Nigerian Journal of Basic and Applied Sciences, 29 (2), 102-111. doi:10.4314/njbas.v29i2.10

Chicago Style

Baraya, Y. S., M. E. Sadiq, J. A. Atata, S. J. Enam, S. Adamu, K. B. Kadima, and N. M. Useh and K. A. N. Esievo. "Clinicopathological Parameters and Sialyltransferase Activity in Trypanosoma Congolense-Infected Sheep." Nigerian Journal of Basic and Applied Sciences 29 (2021), 102-111. doi:10.4314/njbas.v29i2.10

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Baraya, Y. S., Sadiq, . M. E., Atata, . J. A., Enam, . S. J., Adamu, . S., Kadima, . K. B. & (2021) Clinicopathological Parameters and Sialyltransferase Activity in Trypanosoma Congolense-Infected Sheep. Nigerian Journal of Basic and Applied Sciences, 29 (2), 102-111. doi:10.4314/njbas.v29i2.10

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