Antinociceptive Effect of the Ethanol Leaf Extract of Balanites aegyptiaca Linn in Albino Rats

O. A. Sodipo; J. Yakubu; A. M. Dungus and B. Wampana

doi:10.4314/njbas.v27i2.6

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Nig. J. Basic Appl. Sci.. 2019; 27(2): 39-46

doi: 10.4314/njbas.v27i2.6

Antinociceptive Effect of the Ethanol Leaf Extract of Balanites aegyptiaca Linn in Albino Rats

O. A. Sodipo, J. Yakubu, A. M. Dungus and B. Wampana.

Abstract
The research was conducted to investigate the phytochemical constituents, acute toxicity, the anti-inflammatory and antinociceptive activities of the ethanol extract of Balanites aegyptiaca (EEBA) leaves. The anti-inflammatory and antinociceptive activities at doses of 200, 400 and 600 mg/kg i.p were evaluated using hot plate and tail immersion methods (models) in albino rats. EEBA produced significant (p <0.05) and dose dependent anti-inflammatory and antinociceptive activities at all test doses (200, 400 and 600 mg/kg). Phytochemical constituents present in EEBA were found to be flavonoids, carbohydrates, saponins and glycosides which might be responsible for the established anti-inflammatory and antinociceptive activities in the plant extract. The leaf extract of the plant was found to be non-toxic with an intraperitoneal acute toxicity (LD50) of 2254 mg/kg.

Key words: Phytochemical, anti-inflammatory, antinociceptive, Balanites aegyptiaca

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Pubmed Style

Sodipo OA, Yakubu J, . Antinociceptive Effect of the Ethanol Leaf Extract of Balanites aegyptiaca Linn in Albino Rats. Nig. J. Basic Appl. Sci.. 2019; 27(2): 39-46. doi:10.4314/njbas.v27i2.6

Web Style

Sodipo OA, Yakubu J, . Antinociceptive Effect of the Ethanol Leaf Extract of Balanites aegyptiaca Linn in Albino Rats. https://www.njbas-udus.com/?mno=30119 [Access: September 15, 2023]. doi:10.4314/njbas.v27i2.6

AMA (American Medical Association) Style

Sodipo OA, Yakubu J, . Antinociceptive Effect of the Ethanol Leaf Extract of Balanites aegyptiaca Linn in Albino Rats. Nig. J. Basic Appl. Sci.. 2019; 27(2): 39-46. doi:10.4314/njbas.v27i2.6

Vancouver/ICMJE Style

Sodipo OA, Yakubu J, . Antinociceptive Effect of the Ethanol Leaf Extract of Balanites aegyptiaca Linn in Albino Rats. Nig. J. Basic Appl. Sci.. (2019), [cited September 15, 2023]; 27(2): 39-46. doi:10.4314/njbas.v27i2.6

Harvard Style

Sodipo, O. A., Yakubu, . J. & (2019) Antinociceptive Effect of the Ethanol Leaf Extract of Balanites aegyptiaca Linn in Albino Rats. Nig. J. Basic Appl. Sci., 27 (2), 39-46. doi:10.4314/njbas.v27i2.6

Turabian Style

Sodipo, O. A., J. Yakubu, and A. M. Dungus and B. Wampana. 2019. Antinociceptive Effect of the Ethanol Leaf Extract of Balanites aegyptiaca Linn in Albino Rats. Nigerian Journal of Basic and Applied Sciences, 27 (2), 39-46. doi:10.4314/njbas.v27i2.6

Chicago Style

Sodipo, O. A., J. Yakubu, and A. M. Dungus and B. Wampana. "Antinociceptive Effect of the Ethanol Leaf Extract of Balanites aegyptiaca Linn in Albino Rats." Nigerian Journal of Basic and Applied Sciences 27 (2019), 39-46. doi:10.4314/njbas.v27i2.6

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Sodipo, O. A., Yakubu, . J. & (2019) Antinociceptive Effect of the Ethanol Leaf Extract of Balanites aegyptiaca Linn in Albino Rats. Nigerian Journal of Basic and Applied Sciences, 27 (2), 39-46. doi:10.4314/njbas.v27i2.6

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