Fortification of diets with Curcuma longa and Allium cepa ameliorates dioxin-induced dyslipideamia and oxidative stress in Wistar rats

A.S. Idoko; S. Umar; G.O. Adejo; N.U. Imam; A. S. Zaharaddeen; Z. S. Abubakar and 
A. Abdullahi

doi:10.4314/njbas.v30i2.23

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Nig. J. Basic Appl. Sci.. 2022; 30(2): 178-183

doi: 10.4314/njbas.v30i2.23

Fortification of diets with Curcuma longa and Allium cepa ameliorates dioxin-induced dyslipideamia and oxidative stress in Wistar rats

A.S. Idoko, S. Umar, G.O. Adejo, N.U. Imam, A. S. Zaharaddeen, Z. S. Abubakar and A. Abdullahi.

Abstract
Industrial and environmental activities continuously release chemicals such as 2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD) that are hazardous to human health. This research seeks to assess the potentials of Allium cepa and Curcuma longa in suppressing 2,3,7,8-tetracholorodibenzo-p-dioxintoxicity. Forty (40) male Wistar rats weighing 121.77±16.23 g were divided into eight groups of five (5) rats per group. Positive control was fed standard diet, and given 2 µg/kg/week of TCDD in 0.5ml DMSO while normal control was fed standard diet and given 0.5ml dimethyl sulfoxide (DMSO)/kg body weight/week instead of TCDD. Other groups received 2µg/kg/week of TCDD in 0.5ml DMSO and were fed varied inclusion levels of powdered Allium cepa and Curcuma longa. On the 35th day of the experimental period, the rats were sacrificed and serum prepared from collected blood for antioxidant enzymes, malondialdehyde (MDA) and lipid profile determinations. All treated groups had significantly (p<0.05) higher activities of antioxidant enzymes when compared with the positive control. Malondialdehyde concentration was significantly (p<0.05) lower in the treated groups than the positive control (187.87±5.65 nmol/l). Lipid profiles were significantly improved upon by the inclusion of Allium cepa and Curcuma longa. Therefore, we conclude that dyslipidaemia and oxidative stress due to exposure to dioxin in rats could be suppressed by consumption of 2.5% to 5%inclusion levels of powdered onion and/or turmeric in the diet.

Key words: ,3,7,8-tetracholorodibenzo-p-dioxin; glutathione peroxidase; glutathione reductase; malondialdehyde; Allium cepa; Curcuma longa.

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Pubmed Style

Idoko A, Umar S, Adejo G, Imam N, Zaharaddeen AS, . Fortification of diets with Curcuma longa and Allium cepa ameliorates dioxin-induced dyslipideamia and oxidative stress in Wistar rats. Nig. J. Basic Appl. Sci.. 2022; 30(2): 178-183. doi:10.4314/njbas.v30i2.23

Web Style

Idoko A, Umar S, Adejo G, Imam N, Zaharaddeen AS, . Fortification of diets with Curcuma longa and Allium cepa ameliorates dioxin-induced dyslipideamia and oxidative stress in Wistar rats. https://www.njbas-udus.com/?mno=45384 [Access: September 15, 2023]. doi:10.4314/njbas.v30i2.23

AMA (American Medical Association) Style

Idoko A, Umar S, Adejo G, Imam N, Zaharaddeen AS, . Fortification of diets with Curcuma longa and Allium cepa ameliorates dioxin-induced dyslipideamia and oxidative stress in Wistar rats. Nig. J. Basic Appl. Sci.. 2022; 30(2): 178-183. doi:10.4314/njbas.v30i2.23

Vancouver/ICMJE Style

Idoko A, Umar S, Adejo G, Imam N, Zaharaddeen AS, . Fortification of diets with Curcuma longa and Allium cepa ameliorates dioxin-induced dyslipideamia and oxidative stress in Wistar rats. Nig. J. Basic Appl. Sci.. (2022), [cited September 15, 2023]; 30(2): 178-183. doi:10.4314/njbas.v30i2.23

Harvard Style

Idoko, A., Umar, . S., Adejo, . G., Imam, . N., Zaharaddeen, . A. S. & (2022) Fortification of diets with Curcuma longa and Allium cepa ameliorates dioxin-induced dyslipideamia and oxidative stress in Wistar rats. Nig. J. Basic Appl. Sci., 30 (2), 178-183. doi:10.4314/njbas.v30i2.23

Turabian Style

Idoko, A.S., S. Umar, G.O. Adejo, N.U. Imam, A. S. Zaharaddeen, and Z. S. Abubakar and A. Abdullahi. 2022. Fortification of diets with Curcuma longa and Allium cepa ameliorates dioxin-induced dyslipideamia and oxidative stress in Wistar rats. Nigerian Journal of Basic and Applied Sciences, 30 (2), 178-183. doi:10.4314/njbas.v30i2.23

Chicago Style

Idoko, A.S., S. Umar, G.O. Adejo, N.U. Imam, A. S. Zaharaddeen, and Z. S. Abubakar and A. Abdullahi. "Fortification of diets with Curcuma longa and Allium cepa ameliorates dioxin-induced dyslipideamia and oxidative stress in Wistar rats." Nigerian Journal of Basic and Applied Sciences 30 (2022), 178-183. doi:10.4314/njbas.v30i2.23

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Idoko, A., Umar, . S., Adejo, . G., Imam, . N., Zaharaddeen, . A. S. & (2022) Fortification of diets with Curcuma longa and Allium cepa ameliorates dioxin-induced dyslipideamia and oxidative stress in Wistar rats. Nigerian Journal of Basic and Applied Sciences, 30 (2), 178-183. doi:10.4314/njbas.v30i2.23

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