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Toxicity Studies on Aqueous-Methanol Pod Extract of Vigna Unguiculata (Cowpea) in Wistar Strain Albino Rats

ADA FLORENCE OKWUNAKWE, YUSUF SAIDU, SULEIMAN A ISAH, MOHAMMED ACHOR, ABBAS ABDULLAHI YAHAYA.

Abstract
Herbal preparation of Vigna unguiculata (cowpea) pod has long been used by a group of Hausa people from northern Nigeria called Yan tauri performers and traditional healers. This study was conducted to evaluate the toxicological effect of the extract in Wistar strain albino rats using biochemical, haematological and histopathological indices of toxicity. Acute toxicity (LD50) and sub-chronic toxicity studies were determined using the method developed by OECD. Twenty five rats grouped into 5 of 5 each, one of the groups serving as control, were orally administered with the extract at a daily dose of 400 mg/kg, 800 mg/kg, 1200 mg/kg and 1600 mg/kg of the extract respectively for 28 days. The LD50 of the extract was greater than 5000 mg/kg and its oral administration for 28 days did not produce significant changes (P˃0.05) on biochemical and haematological indices. Histopathological evaluation revealed mild widening of Bowmans capsule of animals administered with 1200 mg/kg and 1600 mg/kg of the extract. It can thus be concluded that the pod is non-toxic.

Key words: Vigna unguiculata pod, Yan tauri performers, aqueous-methanol extract, acute and sub-chronic toxicity.


 
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How to Cite this Article
Pubmed Style

OKWUNAKWE AF, SAIDU Y, ISAH SA, ACHOR M, YAHAYA AA. Toxicity Studies on Aqueous-Methanol Pod Extract of Vigna Unguiculata (Cowpea) in Wistar Strain Albino Rats. Nig. J. Basic Appl. Sci.. 2020; 28(2): 1-9. doi:10.4314/njbas.v28i2.1


Web Style

OKWUNAKWE AF, SAIDU Y, ISAH SA, ACHOR M, YAHAYA AA. Toxicity Studies on Aqueous-Methanol Pod Extract of Vigna Unguiculata (Cowpea) in Wistar Strain Albino Rats. http://www.njbas-udus.com/?mno=52684 [Access: March 24, 2021]. doi:10.4314/njbas.v28i2.1


AMA (American Medical Association) Style

OKWUNAKWE AF, SAIDU Y, ISAH SA, ACHOR M, YAHAYA AA. Toxicity Studies on Aqueous-Methanol Pod Extract of Vigna Unguiculata (Cowpea) in Wistar Strain Albino Rats. Nig. J. Basic Appl. Sci.. 2020; 28(2): 1-9. doi:10.4314/njbas.v28i2.1



Vancouver/ICMJE Style

OKWUNAKWE AF, SAIDU Y, ISAH SA, ACHOR M, YAHAYA AA. Toxicity Studies on Aqueous-Methanol Pod Extract of Vigna Unguiculata (Cowpea) in Wistar Strain Albino Rats. Nig. J. Basic Appl. Sci.. (2020), [cited March 24, 2021]; 28(2): 1-9. doi:10.4314/njbas.v28i2.1



Harvard Style

OKWUNAKWE, A. F., SAIDU, . Y., ISAH, . S. A., ACHOR, . M. & YAHAYA, . A. A. (2020) Toxicity Studies on Aqueous-Methanol Pod Extract of Vigna Unguiculata (Cowpea) in Wistar Strain Albino Rats. Nig. J. Basic Appl. Sci., 28 (2), 1-9. doi:10.4314/njbas.v28i2.1



Turabian Style

OKWUNAKWE, ADA FLORENCE, YUSUF SAIDU, SULEIMAN A ISAH, MOHAMMED ACHOR, and ABBAS ABDULLAHI YAHAYA. 2020. Toxicity Studies on Aqueous-Methanol Pod Extract of Vigna Unguiculata (Cowpea) in Wistar Strain Albino Rats. Nigerian Journal of Basic and Applied Sciences, 28 (2), 1-9. doi:10.4314/njbas.v28i2.1



Chicago Style

OKWUNAKWE, ADA FLORENCE, YUSUF SAIDU, SULEIMAN A ISAH, MOHAMMED ACHOR, and ABBAS ABDULLAHI YAHAYA. "Toxicity Studies on Aqueous-Methanol Pod Extract of Vigna Unguiculata (Cowpea) in Wistar Strain Albino Rats." Nigerian Journal of Basic and Applied Sciences 28 (2020), 1-9. doi:10.4314/njbas.v28i2.1



MLA (The Modern Language Association) Style

OKWUNAKWE, ADA FLORENCE, YUSUF SAIDU, SULEIMAN A ISAH, MOHAMMED ACHOR, and ABBAS ABDULLAHI YAHAYA. "Toxicity Studies on Aqueous-Methanol Pod Extract of Vigna Unguiculata (Cowpea) in Wistar Strain Albino Rats." Nigerian Journal of Basic and Applied Sciences 28.2 (2020), 1-9. Print. doi:10.4314/njbas.v28i2.1



APA (American Psychological Association) Style

OKWUNAKWE, A. F., SAIDU, . Y., ISAH, . S. A., ACHOR, . M. & YAHAYA, . A. A. (2020) Toxicity Studies on Aqueous-Methanol Pod Extract of Vigna Unguiculata (Cowpea) in Wistar Strain Albino Rats. Nigerian Journal of Basic and Applied Sciences, 28 (2), 1-9. doi:10.4314/njbas.v28i2.1





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